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The Importance Of The Macrophage In The Immune System

We could depict it as a Pac-Man that eats up all the unwanted “ghosts”, but the macrophage does more than just that.


Dr Joel Yong

4 months ago | 2 min read


We could depict it as a Pac-Man that eats up all the unwanted “ghosts”, but the macrophage does more than just that.

The macrophage is one of those immune cells in our body that does quite a fair bit of things without us thinking about it.

We’re exposed to so many microbes and virues in the environment on a daily basis, and some of them can penetrate through the skin and mucosal barriers that act as the first line of defence to those foreign invaders:

The macrophages exist in our body as part of the immune system. As an article at Duke University does mention,

Macrophages are known as the Pac-Man of the immune system and form the body’s first line of defense against invasion — they indiscriminately engulf and eat most anything deemed a dangerous trespasser, whether it’s a bacterium or cellular debris from deceased tissue.

And that’s where we can consider the macrophage as a Pac Man type of cell. They engulf any other type of cell or cellular debris from deceased tissue and then “eat” and digest those biological components down into simpler constituents.

That’s the primary purpose of the macrophage cells in the human body.

Of course, these macrophage cells don’t just have one singular function.

They can digest cholesterol particles too.

They are able to engulf and digest low density lipoprotein (LDL) particles.

However, if those LDL particles were oxidised (oxLDL), the CD36 receptors on the macrophages would signal the macrophages to consume the oxLDL uncontrollably, which turns them into fatty foam cells that settle onto arterial walls and form the basis of atherosclerotic plaques.

And that isn’t good because it can lead into the development of heart disease — which invariably has an immunological link to it because of macrophage activity.

They can digest extracellular debris.

When we injure ourselves, there will be some cells that end up dying. A cut on our skin causes some fibres on our skin to get frayed, for instance.

The macrophages are responsible for clearing out those dead or damaged fragments so that new connections can be synthesised to stitch up the damage:

They do so by producing “digestive” enzymes such as matrix metalloproteinase enzymes (MMPs) to digest away all the dead cells and extracellular debris left behind by the injury.

The problem being that these MMPs are also able to digest the collagen cap that covers an atherosclerotic plaque, and also digest away joint cartilage in the development of osteoarthritis.

They digest red blood cells and act as an iron store.

There are so many red blood cells (RBCs) in the body that function as oxygen transporters. These RBCs have a life span of 110–120 days on average before they die.

Of course, the macrophages are there to digest the dead RBCs, and in doing so end up storing the iron in the haemoglobin proteins that the RBCs contain to transport oxygen around the body.

They are controlled by signalling mechanisms

There are complex biochemical signalling mechanisms involved in getting these macrophages active. These guys are consistently on the alert, much like an army battalion that is taking a defensive stance in war.

The battalion does not needlessly go out to attack — but it is on alert to defend itself from any attacks.

Unfortunately, sometimes, the battalion may receive the wrong information and end up opening fire on innocent or friendly targets.

That is what happens in the case of an autoimmune disorder — the problem with rheumatoid arthritis arises as a macrophage infiltration issue, where the macrophages are given misdirected orders to attack benign joint cartilage that has otherwise been earmarked as a threat to the human body.

And of course, signalling errors can cause the macrophages to hold on to their iron content instead of releasing them back into the blood:


Created by

Dr Joel Yong


Educator | Biochemical Scientist

Deconstructing the interconnectedness between health and business. Join my mailing list at or book a one-on-one consultation session with me at







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